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Atlantis is said to be a submerged lost city in the Atlantic ocean on Earth-1. However, on Earth-2 the island city is above water and a popular place to visit among the Earth-2 people.
It was mentioned that Earth-2 Barry got his parents tickets to Atlantis for their anniversary because they had always wanted to go. Later, Hunter Zolomon mentioned he was fond of Atlantis and that one of his good friends was from there. Wells also pulled up a map of Earth-2 which featured a large island west of Europe- an island that does not exist on Earth-1 so it can presumably be Atlantis.