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S.T.A.R. Laboratories is a research facility located in Central City. It's acronym stands for Scientific and Technological Advanced Research Laboratories. It contains various science equipment and is an active organization, that currently serves as the headquarters for the Flash and his team.
- Hartley Rathaway
- Harrison Wells (real) (deceased)
- Ronnie Raymond (deceased)
- Arthur Light (fired due to insanity)
S.T.A.R. Labs once created a particle accelerator, under Harrison Wells (in disguise), that malfunctioned and severely injured and or killed many people. Several others were also mutated and became meta-humans. Since then, S.T.A.R. Labs has been disgraced and categorized as a class four hazard location. They've not been able to rebuild to their former glory, so currently it acts as a base of operations for Team Flash. It was also a former meta-human prison, the pipeline beneath the building was used in place of cells for dangerous supervillains.
- Mercury Labs, in the Flash comics, is often depicted as a rival laboratory to S.T.A.R Labs.